Journal
JOURNAL OF BIOMOLECULAR NMR
Volume 51, Issue 4, Pages 457-465Publisher
SPRINGER
DOI: 10.1007/s10858-011-9574-5
Keywords
Serum; Proton NMR; Preanalytical variation; Biobank; Biomarker; Biospecimen research; Metabolic profiling
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Funding
- Conseil Regional de Picardie
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A blood pre-centrifugation delay of 24 h at room temperature influenced the proton NMR spectroscopic profiles of human serum. A blood pre-centrifugation delay of 24 h at 4A degrees C did not influence the spectroscopic profile as compared with 4 h delays at either room temperature or 4A degrees C. Five or ten serum freeze-thaw cycles also influenced the proton NMR spectroscopic profiles. Certain common in vitro preanalytical variations occurring in biobanks may impact the metabolic profile of human serum.
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