Journal
JOURNAL OF BIOMOLECULAR NMR
Volume 42, Issue 3, Pages 155-158Publisher
SPRINGER
DOI: 10.1007/s10858-008-9277-8
Keywords
NMR structure determination of proteins; Protein biochemistry; Automation; Structural biology; Structural genomics
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Funding
- EU [LSHG-CT-2005-018988]
- NIH [47467]
- Joint Center for Structural Genomics in La Jolla, CA, USA (JCSG, NIH) [GM074898]
- CCR Structural Biology (Swiss National Science Foundation and ETH Zurich, Switzerland)
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This 'Perspective' bears on the present state of protein structure determination by NMR in solution. The focus is on a comparison of the infrastructure available for NMR structure determination when compared to protein crystal structure determination by X-ray diffraction. The main conclusion emerges that the unique potential of NMR to generate high resolution data also on dynamics, interactions and conformational equilibria has contributed to a lack of standard procedures for structure determination which would be readily amenable to improved efficiency by automation. To spark renewed discussion on the topic of NMR structure determination of proteins, procedural steps with high potential for improvement are identified.
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