Journal
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
Volume -, Issue -, Pages -Publisher
HINDAWI PUBLISHING CORPORATION
DOI: 10.1155/2012/493945
Keywords
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Funding
- Japan Ministry of Education, Culture, Sports, Science, and Technology
- Core Research for Evolutional Science and Technology
- Fuso Pharmaceutical Industry, Co.
- Smoking Research Foundation
- Takeda Science Foundation
- Mizutani Foundation Glycoscience
- Grants-in-Aid for Scientific Research [22390113, 22590259] Funding Source: KAKEN
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Collectins are characterized by a collagen-like sequence and a carbohydrate recognition domain and are members of the vertebrate C-type lectin superfamily. Recently, novel collectins, different from classical collectins consisting of mannan-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D), have been found by reverse genetics. These novel collectins consist of collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1), and collectin placenta 1 (CL-P1) and are encoded by three separate genes. Experimental findings on human and animal collectins have shown that both novel collectins and classical collectins play an important role in innate immunity. Based on our recent results and those of others, in this paper, we summarize the new biological functions of these novel collectins in embryonic morphogenesis and development.
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