Journal
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
Volume -, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2010/182581
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Funding
- Biotechnology and Biological Sciences Research Council [BB/G010323/1] Funding Source: Medline
- Medical Research Council [G0300484] Funding Source: Medline
- Medical Research Council [G0700711B] Funding Source: researchfish
- BBSRC [BB/G010323/1] Funding Source: UKRI
- MRC [G0300484] Funding Source: UKRI
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Dielectrophoresis can discriminate distinct cellular identities in heterogeneous populations, and monitor cell state changes associated with activation and clonal expansion, apoptosis, and necrosis, without the need for biochemical labels. Demonstrated capabilities include the enrichment of haematopoetic stem cells from bone marrow and peripheral blood, and adult stem cells from adipose tissue. Recent research suggests that this technique can predict the ultimate fate of neural stem cells after differentiation before the appearance of specific cell-surface proteins. This review summarises the properties of cells that contribute to their dielectrophoretic behaviour, and their relevance to stem cell research and translational applications.
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