Journal
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
Volume -, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2009/595126
Keywords
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Funding
- National 863 Project [2007AA021902]
- National Natural Science Foundation [NSFC20704027]
- Specialized Research Fund for the Doctoral Program of Higher Education [SRFDP 200806100065]
- New Century Excellent Talents in University [NCET-08-0371]
- Sichuan Key Project of Science and Technology [2007SGY019]
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A biodegradable sponge, composed of chitosan (CS) and sodium alginate (SA), was successfully obtained in this work. The sponge was ethereal and pliable. The chemical structure and morphology of the sponges was characterized by FTIR and SEM. The swelling ability, in vitro drug release and degradation behaviors, and an in vivo animal test were employed to confirm the applicability of this sponge as a wound dressing material. As the chitosan content in the sponge decreased, the swelling ability decreased. All types of the sponges exhibited biodegradable properties. The release of curcumin from the sponges could be controlled by the crosslinking degree. Curcumin could be released from the sponges in an extended period for up to 20 days. An in vivo animal test using SD rat showed that sponge had better effect than cotton gauze, and adding curcumin into the sponge enhanced the therapeutic healing effect. Copyright (C) 2009 Mei Dai et al.
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