Journal
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
Volume -, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2009/181282
Keywords
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Funding
- National Natural Science Foundation of China [40590390, 30671734]
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One,1-dichloro-2,2 bis(p-chlorophenyl) ethylene (p,p'-DDE), the major metabolite of 2,2-bis(4-Chlorophenyl)-1,1,1-trichloroethane (DDT), is a known persistent organic pollutant and male reproductive toxicant. It has antiandrogenic effect. However, the mechanism by which p,p'-DDE exposure causes male reproductive toxicity remains unknown. In the present study, rat Sertoli cells were used to investigate the molecular mechanism involved in p, p'-DDE-induced toxicity in male reproductive system. The results indicated that p,p'-DDE exposure at over 30 mu M showed the induction of apoptotic cell death. p,p'-DDE could induce increases in FasL mRNA and protein, which could be blocked by an antioxidant agent, N-acetyl-l-cysteine (NAC). In addition, caspase-3 and -8 were activated by p,p'-DDE treatment in these cells. The activation of NF-kappa B was enhanced with the increase of p,p'-DDE dose. Taken together, these results suggested that exposure to p, p'-DDE might induce apoptosis of rat Sertoli cells through a FasL-dependent pathway. Copyright (C) 2009
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