Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 23, Issue 12, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.23.12.121608
Keywords
optical properties; tissue; skin; scattering; spectroscopy
Funding
- Sweden's innovation agency VINNOVA via the program MedTech4Health [2016-02211]
- Swedish Heart and Lung Foundation
- Knut and Alice Wallenberg Foundation
- Swedish Research Council
- VINNOVA
- Vinnova [2016-02211] Funding Source: Vinnova
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We have determined in vivo optical scattering properties of normal human skin in 1734 subjects, mostly with fair skin type, within the Swedish CArdioPulmonary bioImage Study. The measurements were performed with a noninvasive system, integrating spatially resolved diffuse reflectance spectroscopy and laser Doppler flowmetry. Data were analyzed with an inverse Monte Carlo algorithm, accounting for both scattering, geometrical, and absorbing properties of the tissue. The reduced scattering coefficient was found to decrease from 3.16 +/- 0.72 to 1.13 +/- 0.27 mm(-1) (mean +/- SD) in the 475- to 850-nm wavelength range. There was a negative correlation between the reduced scattering coefficient and age, and a significant difference between men and women in the reduced scattering coefficient as well as in the fraction of small scattering particles. This large study on tissue scattering with mean values and normal variation can serve as a reference when designing diagnostic techniques or when evaluating the effect of therapeutic optical systems. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
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