Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 19, Issue 7, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.19.7.077006
Keywords
liquid-crystal-based immunodetection; cancer biomarker; CA125; label-free immunodetection
Funding
- Ministry of Science and Technology, Taiwan [NSC 101-2112-M-009-018-MY3, NSC 101-2314-B-309-001-MY3]
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A label-free and array-based optical liquid-crystal (LC) immunodetection technique for the detection of CA125 antigen, a protein biomarker most frequently used for ovarian cancer detection, was demonstrated with a nematic LC with larger birefringence (Delta n) to promote sensitivity in detecting biomolecules. The LC-based immunodetection offers an alternative and sensitive approach for the detection of biomarker proteins, with the potential of replacing conventional immunoassays used in biochemical studies and clinical laboratories. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
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