Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 19, Issue 10, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.19.10.106014
Keywords
retinal scanning; pupil dynamics; dark adaptation; fixation; accommodation
Funding
- Hartwell Foundation
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While validating our newly developed vision screener based on a double-pass retinal scanning system, we noticed that in all patients the signals from the retina were significantly higher when measurements were performed within a certain time interval referenced to the initial moment when the lights were dimmed and the test subject was asked to fixate on a target. This appeared to be most likely attributable to pupil size dynamics and triggered the present study, whose aim was to assess the pupillary lights-off response while fixating on a target in the presence of an accommodative effort. We found that pupil size increases in the first 60 to 70 s after turning off the room lights, and then it decreases toward the baseline in an exponential decay. Our results suggest that there is an optimal time window during which pupil size is expected to be maximal, that is during the second minute after dimming the room lights. During this time, window retinal diagnostic instruments based on double-pass measurement technology should deliver an optimal signal-to-noise ratio. We also propose a mathematical model that can be used to approximate the behavior of the normalized pupil size. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
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