Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 18, Issue 12, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.18.12.121503
Keywords
optical coherence tomography; surface elastic wave; mouse cornea; air puff; Young's modulus; noninvasive detection
Funding
- NIH/NEI [1R01EY022362, P30EY07551]
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We demonstrate the use of phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves induced by a focused air-pulse system in tissue-mimicking phantoms, a contact lens, a silicone eye model, and the mouse cornea in vivo. The results show that the wave velocity can be quantified from the analysis of wave propagation, thereby enabling the estimation of the sample elasticity using the model of surface wave propagation for the tissue-mimicking phantoms. This noninvasive, non-contact measurement technique involves low-force methods of tissue excitation that can be potentially used to assess the biomechanical properties of ocular and other delicate tissues in vivo. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
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