Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 18, Issue 12, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.18.12.121510
Keywords
optical coherence tomography; elastography; needle probe; breast cancer; mechanical properties
Funding
- National Breast Cancer Foundation, Australia
- Scholarship for International Research Fees, UWA
- Cancer Council Western Australia
- Raine Medical Research Foundation
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Optical coherence elastography (OCE) is an emerging imaging technique that probes microscale mechanical contrast in tissues with the potential to differentiate healthy and malignant tissues. However, conventional OCE techniques are limited to imaging the first 1 to 2 mm of tissue in depth. We demonstrate, for the first time, OCE measurements deep within human tissues using needle OCE, extending the potential of OCE as a surgical guidance tool. We use needle OCE to detect tissue interfaces based on mechanical contrast in both normal and malignant breast tissues in freshly excised human mastectomy samples, as validated against histopathology. Further, we demonstrate the feasibility of in situ measurements >4 cm from the tissue surface using ultrasound guidance of the OCE needle probe. With further refinement, our method may potentially aid in accurate detection of the boundary of the tumor to help ensure full removal of all malignant tissues, which is critical to the success of breast-conserving surgery. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
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