Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 17, Issue 6, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.17.6.066022
Keywords
optical clearing; optical coherence tomography; chemical penetration enhancer; physical massage
Funding
- National Nature Science Foundation of China [81171376]
- Research Fund for the Doctoral Program of Higher Education of China [20110142110073]
- NSFC-RFBR for the International Cooperation (RF-China) [30911120074, RFBR-08-02-92224-NNSF_a]
- RF [02.740.11.0879, 1.4.09]
- FiDiPro
- TEKES, Finland [40111/11]
- [224014 Photonics4life-FP7-ICT-2007-2]
- [RF 2.1.1/4989, 2.2.1.1/2950,1.4.09]
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The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 mu m depth and 31% enhancement in image depth Z(threshold). (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.6.066022]
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