Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 17, Issue 7, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.17.7.070501
Keywords
optical coherence tomography; fluorescence; atherogenesis; double-clad fiber; annexin V
Funding
- NIH [R01EB-10090, R01HL-105215, K25HL-102055, P41-EB2182]
- AFOSR [FA9550-08-1-0384]
- China Scholarship Council (CSC)
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We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as image display. For fluorescence imaging, the inflammation of atherosclerosis and necrotic core formed with the annexin V conjugated Cy5.5 were imaged. Ex vivo imaging of New Zealand white rabbit arteries demonstrated the capability of the combined system. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.7.070501
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