Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 18, Issue 3, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.18.3.031102
Keywords
second-order susceptibility; second harmonic generation; collagen; polarization-resolved microscopy
Funding
- National Science Council [NSC 101-2112-M-002-003-MY3, NSC 99-2221-E-002-008-MY3, NSC 100-2314-B-418-009]
- National Health Research Institute [NHRI-EX10010041EI]
- Center of Quantum Science and Engineering [CQSE-10R80914]
- National Taiwan University [NTU-101R70804]
- World Class University (WCU) program of Korea
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We discuss the recent advances in the development and applications of second-order susceptibility as a contrast mechanism in optical microscopy for biological tissues. We review nonlinear optical methods and approaches for differentiation of tissue structures and discrimination of normal and pathological skin tissues, which have been demonstrated for the potential use in clinical diagnosis. In addition, the potential of second-order susceptibility imaging, encompassing applications in differentiating various types of collagen molecules for clinical diagnosis, is demonstrated. Finally, we discuss future development and application of this technique. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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