Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 17, Issue 1, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.17.1.016015
Keywords
gold-coated magnetic silica nanoparticle; multifunctional contrast agent; scattering-based optical coherence tomography; photothermal optical coherence tomography; magnetomotive photoacoustic imaging
Funding
- National Institutes of Health [R01 HL093140, R01 HL093140S, R01 EB009682, R01 DC010201]
- American Heart Association [0855733G]
- Life Sciences Discovery Fund of the State of Washington [3292512]
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Several imaging modalities such as optical coherence tomography, photothermal, photoacoustic and magnetic resonance imaging, are sensitive to different physical properties (i.e. scattering, absorption and magnetic) that can provide contrast within biological tissues. Usually exogenous agents are designed with specific properties to provide contrast for these imaging methods. In nano-biotechnology there is a need to combine several of these properties into a single contrast agent. This multifunctional contrast agent can then be used by various imaging techniques simultaneously or can be used to develop new imaging modalities. We reported and characterized a multifunctional nanoparticle, made from gold nanoshells, which exhibits scattering, photothermal, photoacoustic, and magnetic properties. (c) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.1.016015]
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