Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 16, Issue 9, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3619139
Keywords
photoacoustic tomography; image reconstruction; autofocus; sound speed; in vivo imaging
Funding
- Australian Research Council/Microsoft Linkage [LP100100588]
- Engineering and Physical Sciences Research Council, UK
- EPSRC [EP/H005536/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/H005536/1] Funding Source: researchfish
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The reconstruction of images in photoacoustic tomography is reliant on specifying the speed of sound within the propagation medium. However, for in vivo imaging, this value is not normally accurately known. Here, an autofocus approach for automatically selecting the sound speed is proposed. This is based on maximizing the sharpness of the reconstructed image as quantified by a focus function. Several focus functions are investigated, and their performance is discussed. The method is demonstrated using phantom measurements made in a medium with a known sound speed and in vivo measurements of the vasculature in the flank of an adult mouse. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3619139]
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