Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 16, Issue 7, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3599955
Keywords
diffuse optical tomography; dynamic imaging; digital signal processor; digital detection; breast cancer; continuous wave; optical instrumentation; optical mammography
Funding
- National Institutes of Health [R41CA096102]
- US Army [DAMD017-03-C-0018]
- Susan G. Komen Foundation
- New York State Office of Science, and Technology and Academic Research (NYSTAR) [C020041]
- NIRx Medical Technologies
- Natural Sciences and Engineering Research Council of Canada (NSERC)
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Diffuse optical tomography has shown promising results as a tool for breast cancer screening and monitoring response to chemotherapy. Dynamic imaging of the transient response of the breast to an external stimulus, such as pressure or a respiratory maneuver, can provide additional information that can be used to detect tumors. We present a new digital continuous-wave optical tomography system designed to simultaneously image both breasts at fast frame rates and with a large number of sources and detectors. The system uses a master-slave digital signal processor-based detection architecture to achieve a dynamic range of 160 dB and a frame rate of 1.7 Hz with 32 sources, 64 detectors, and 4 wavelengths per breast. Included is a preliminary study of one healthy patient and two breast cancer patients showing the ability to identify an invasive carcinoma based on the hemodynamic response to a breath hold. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3599955]
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