Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 16, Issue 7, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3600708
Keywords
spatially offset Raman spectroscopy; breast cancer; margin evaluation; Monte Carlo simulation
Funding
- Department of Defense [W81XWH-09-1-0037]
- National Institutes of Health [R01-AR-055222, R01-CA-114542]
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The risk of local recurrence for breast cancers is strongly correlated with the presence of a tumor within 1 to 2 mm of the surgical margin on the excised specimen. Previous experimental and theoretical results suggest that spatially offset Raman spectroscopy (SORS) holds much promise for intraoperative margin analysis. Based on simulation predictions for signal-to-noise ratio differences among varying spatial offsets, a SORS probe with multiple source-detector offsets was designed and tested. It was then employed to acquire spectra from 35 frozen-thawed breast tissue samples in vitro. Spectra from each detector ring were averaged to create a composite spectrum with biochemical information covering the entire range from the tissue surface to similar to 2 mm below the surface, and a probabilistic classification scheme was used to classify these composite spectra as negative or positive margins. This discrimination was performed with 95% sensitivity and 100% specificity, or with 100% positive predictive value and 94% negative predictive value. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3600708]
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