Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 16, Issue 9, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3625576
Keywords
photoacoustic computed tomography; 3D reconstruction; mouse embryo; focal line
Funding
- National Institutes of Health [R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, 5P60 DK02057933, R01 DE018500]
- National Science Foundation [BCS 0725227]
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A full ring ultrasonic array-based photoacoustic tomography system was recently developed for small animal brain imaging. The 512-element array is cylindrically focused in the elevational direction, and can acquire a two-dimensional (2D) image in 1.6 s. In this letter, we demonstrate the three-dimensional (3D) imaging capability of this system. A novel 3D reconstruction algorithm was developed based on the focal-line concept. Compared to 3D images acquired simply by stacking a series of 2D images, the 3D focal-line reconstruction method renders images with much less artifacts, and improves the elevational resolution by 30% and the signal-to-noise ratio by two times. The effectiveness of the proposed algorithm was first validated by numerical simulations and then demonstrated with a hair phantom experiment and an ex vivo mouse embryo experiment. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3625576]
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