Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 15, Issue 1, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3302807
Keywords
photoacoustic tomography; real time; noninvasive
Funding
- National Institutes of Health [R01 EB000712, R01 EB008085, U54 CA136398]
- NATIONAL CANCER INSTITUTE [U54CA136398] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB008085, R01EB000712] Funding Source: NIH RePORTER
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For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) in real time. The PAT system, based on a 512-element full-ring ultrasound array, received photoacoustic signals primarily from a slice of 2-mm thickness. This system can provide high-resolution brain vasculature images. We also monitored the fast wash-in process of a photoacoustic contrast agent in the mouse brain. Our results demonstrated that PAT is a powerful imaging modality that can be potentially used to study small animal neurofunctional activities. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3302807]
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