Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 15, Issue 3, Pages -Publisher
SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3449109
Keywords
fluorescence; imaging; image processing; molecules; fluorescence spectroscopy; image analysis
Funding
- NIH [P01CA84203, R01CA109558]
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An approach to quantitatively image targeted-agent binding rate in vivo is demonstrated with dual-probe injection of both targeted and nontargeted fluorescent dyes. Images of a binding rate constant are created that reveal lower than expected uptake of epidermal growth factor in an orthotopic xenograft pancreas tumor (2.3 x 10(-5) s(-1)), as compared to the normal pancreas (3.4 x 10(-5) s(-1)). This approach allows noninvasive assessment of tumor receptor targeting in vivo to determine the expected contrast, spatial localization, and efficacy in therapeutic agent delivery. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3449109]
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