Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 15, Issue 2, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3333545
Keywords
imaging systems; photoacoustics; ultrasonics; optical systems; optics
Funding
- NCI NIH HHS [U54 CA136398] Funding Source: Medline
- NCRR NIH HHS [P41 RR011795-04, P41 RR011795] Funding Source: Medline
- NIBIB NIH HHS [R01 EB008085, R01 EB000712, P41 EB002182] Funding Source: Medline
- NINDS NIH HHS [R01 NS046214, R01 NS46214] Funding Source: Medline
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With a refined ultrasound-array-based real-time photoacoustic microscopy (UA-PAM) system, we demonstrate the feasibility of noninvasive in vivo imaging of human pulsatile dynamics. The system, capable of real-time B-scan imaging at 50 Hz and high-speed 3-D imaging, is validated by imaging the subcutaneous microvasculature in rats and humans. After the validation, a human artery around the palm-wrist area is imaged, and its pulsatile dynamics, including the arterial pulsatile motion and changes in hemoglobin concentration, is monitored with 20-ms B-scan imaging temporal resolution. To our knowledge, this is the first demonstration of real-time photoacoustic imaging of human physiological dynamics. Our results show that UA-PAM can potentially enable many new possibilities for studying functional and physiological dynamics in both preclinical and clinical imaging settings. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3333545]
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