Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 15, Issue 3, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3456369
Keywords
digital holography; dynamic light scattering; dynamic speckle; cellular dynamics
Funding
- National Science Foundation [CBET-0756005]
- STX Foundation
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Dynamic speckle from 3-D coherence-gated optical sections provides a sensitive label-free measure of cellular activity up to 1 mm deep in living tissue. However, specificity to cellular functionality has not previously been demonstrated. In this work, we perform fluctuation spectroscopy on dynamic light scattering captured using coherence-domain digital holography to obtain the spectral response of tissue that is perturbed by temperature, osmolarity, and antimitotic cytoskeletal drugs. Different perturbations induce specific spectrogram response signatures that can show simultaneous enhancement and suppression in different spectral ranges. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3456369]
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