Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 14, Issue 4, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3194291
Keywords
Barrett's esophagus; classification; elastic scattering spectroscopy; linear discriminant analysis; orthogonal projection; pretreatment; principal component analysis; replicated measurements
Funding
- Peacock Trust
- National Cancer Institute Network for Translational Research into Optical Imaging (NTROI) of NIH
- Experimental Cancer Medicine Centre (ECMC)
- Comprehensive Biomedical Research Centre (CBRC)
- National Institute for Health Research [II-FS-0509-12051] Funding Source: researchfish
- NATIONAL CANCER INSTITUTE [U54CA104677] Funding Source: NIH RePORTER
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Elastic scattering spectroscopy (ESS) may be used to detect high-grade dysplasia (HGD) or cancer in Barrett's esophagus (BE). When spectra are measured in vivo by a hand-held optical probe, variability among replicated spectra from the same site can hinder the development of a diagnostic model for cancer risk. An experiment was carried out on excised tissue to investigate how two potential sources of this variability, pressure and angle, influence spectral variability, and the results were compared with the variations observed in spectra collected in vivo from patients with Barrett's esophagus. A statistical method called error removal by orthogonal subtraction (EROS) was applied to model and remove this measurement variability, which accounted for 96.6% of the variation in the spectra, from the in vivo data. Its removal allowed the construction of a diagnostic model with specificity improved from 67% to 82% (with sensitivity fixed at 90%). The improvement was maintained in predictions on an independent in vivo data set. EROS works well as an effective pretreatment for Barrett's in vivo data by identifying measurement variability and ameliorating its effect. The procedure reduces the complexity and increases the accuracy and interpretability of the model for classification and detection of cancer risk in Barrett's esophagus. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3194291]
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