Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 14, Issue 3, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3130323
Keywords
optical coherence tomography; optical contrast agent; gold nanoparticles; enhanced delivery; ultrasound; microneedles
Funding
- National Institutes of Health [EB-00293, NCI-91717, RR-01192]
- Air Force Office of Scientific Research [FA9550-04-1-0101]
- University of California Cancer Center [5P30CA062203-13]
- University of California-Irvine (UCI) Council
- UCI
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Contrast in optical coherence tomography (OCT) images can be enhanced by utilizing surface plasmon resonant gold nanoparticles. To improve the poor in vivo transport of gold nanoparticles through biological barriers, an efficient delivery strategy is needed. In this study, the improved penetration and distribution of gold nanoparticles were achieved by microneedle and ultrasound, respectively, and it was demonstrated that this multimodal delivery of antibody-conjugated PEGylated gold nanoparticles enhanced the contrast in in vivo OCT images of oral dysplasia in a hamster model. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3130323]
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