Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 14, Issue 1, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3083427
Keywords
PpIX-encapsulated silica nanoparticles; fluorescence imaging; uptake; photodynamic therapy
Funding
- multidisciplinary project of Zhejiang University
- Swedish Foundation for Strategic Research (SSF)
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Protoporphyrin IX (PpIX)-encapsulated mesoporous silica nanoparticles were synthesized, characterized, and utilized for photodynamic therapy (PDT) of cancer. Silica encapsulation is relatively transparent for activated light and can protect the PpIX against denaturation induced by the extreme bioenvironment. The mesoporous silica can also ensure that the encapsulated PpIX can be well-contacted with oxygen, stimulated, and released. PpIX-encapsulated colloidal mesoporous silica nanoparticles were uptaken by tumor cells in vitro, and the effect of photon-induced toxicity was demonstrated after comparison with some control experiments. The surface of PpIX-encapsulated silica nanoparticles can be grafted with appropriate functionalized groups and conjugated with certain biomolecules for specific targeting. (c) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3083427]
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