Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 14, Issue 6, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3269677
Keywords
breath analysis; laser spectroscopy; carbon monoxide; methane; cavity enhanced absorption spectroscopy
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We demonstrate a first application, of optical-feedback cavity-enhanced absorption spectroscopy (OF-CEAS) to breath analysis in a medical environment. Noninvasive monitoring of trace species in exhaled air was performed simultaneous to spirometric measurements on patients at Bichat Hospital (Paris). The high selectivity of the OF-CEAS spectrometer and a time response of 0.3 s (limited by sample flow rate) allowed following the evolution of carbon monoxide and methane concentrations during individual respiratory cycles, and resolving variations among different ventilatory patterns. The minimum detectable absorption on this time scale is about 3 x 10(-10) cm(-1). At the working wavelength of the instrument (2.326 mu m), this translates to concentration detection limits of similar to 1 ppbv (45 picomolar, or similar to 1.25 mu g/m(3)) for CO and 25 ppbv for CH4, well below concentration values found in exhaled air. This same instrument is also able to provide measurement of NH3 concentrations with a detection limit of similar to 10 ppbv; however, at present, memory effects do not allow its measurement on fast time scales. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3269677]
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