Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 14, Issue 1, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3065542
Keywords
melanin concentration; diffuse remittance; isosbestic point; oxygen saturation; penetration depth
Funding
- NIH [K24 IRT]
- NIBIB [EB-02495-02]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR001192] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB002495] Funding Source: NIH RePORTER
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Objective quantification of epidermal melanin concentration (EMC) should be useful in laser dermatology to determine the individual maximum safe radiant exposure (IMSRE). We propose a single-wavelength remittance measurement at 390 nm as an alternative optical method to determine EMC and IMSRE. Remittance spectra (360 to 740 nm), melanin index (MI) measurements and the transient radiometric temperature increase, Delta T(t), upon skin irradiation with an Alexandrite laser (755 nm, 3-ms pulse duration, 6 J/cm(2)) were measured on 749 skin spots (arm and calf) on 23 volunteers (skin phototypes I to IV). Due to the shallow penetration depth and independence of blood oxygen saturation (isosbestic point), remittance at 390 nm appears to provide better estimates for EMC and IMSRE than MI. (c) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3065542]
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