Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 13, Issue 3, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.2939068
Keywords
photodynamic therapy; spectroscopy; reflectance; fluorescence; Pc 4; clinical trials
Funding
- NCI NIH HHS [R01 CA122093, R01 CA122093-02, CA122093] Funding Source: Medline
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Silicon phthalocyanine. Pc 4 photodynamic therapy (Pc 4-PDT) has emerged as a potentially effective treatment for cutaneous T-cell lymphoma (CTCL). Noninvasive reflectance and fluorescence spectroscopy before, during, and after PDT may provide useful dose metrics and enable therapy to be tailored to individual lesions. We present the design and implementation of a portable bedside spectroscopy system for initial clinical trials of Pc 4-PDT of CTCL. Reflectance and fluorescence spectra were obtained from an early stage CTCL patient throughout the course of the PDT treatment. Preliminary patient data show a significant effect of Pc 4 on the tissue absorption, modest Pc 4 photobleaching, and heterogeneity of Pc 4 within and between the lesions. (c) 2008 Society of Photo-Optical Instrumentation Engineers.
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