Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 13, Issue 6, Pages -Publisher
SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3041500
Keywords
diffuse reflectance spectroscopy; spectral imaging
Funding
- Department of Defense Breast Cancer Research Program (DOD BRCP) Era of Hope Scholar
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A hybrid optical device that uses a multimode fiber coupled to a tunable light source for illumination and a 2.4-mm photodiode for detection in contact with the tissue surface is developed as a first step toward our goal of developing a cost-effective, miniature spectral imaging device to map tissue optical properties in vivo. This device coupled with an inverse Monte Carlo model of reflectance is demonstrated to accurately quantify tissue absorption and scattering in tissue-like turbid synthetic phantoms with a wide range of optical properties. The overall errors for quantifying the absorption and scattering coefficients are 6.0 +/- 5.6 and 6.1 +/- 4.7%, respectively. Compared with fiber-based detection, having the detector right at the tissue surface can significantly improve light collection efficiency, thus reducing the requirement for sophisticated detectors with high sensitivity, and this design can be easily expanded into a quantitative spectral imaging system for mapping tissue optical properties in vivo. (C) 2008 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3041500]
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