Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 13, Issue 2, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.2892687
Keywords
transcutaneous; optical clearing; Raman spectroscopy; bone; fiber optic probe
Funding
- NIAMS NIH HHS [P30 AR46024, R01 AR052010-03, P30 AR046024, R01 AR052010] Funding Source: Medline
- NIA NIH HHS [AG014824] Funding Source: Medline
- NIDDK NIH HHS [T90 DK070071-03, T90 DK070071] Funding Source: Medline
- NIGMS NIH HHS [T32 GM145304, T32 GM008353] Funding Source: Medline
Ask authors/readers for more resources
The effect of optical clearing with glycerol on the Raman spectra of bone tissue acquired transcutaneously on right and left tibiae from four mice is studied. Multiple transcutaneous measurements are obtained from each limb; glycerol is then applied as an optical clearing agent, and additional transcutaneous measurements are taken. Glycerol reduces the noise in the raw spectra (p = 0.0037) and significantly improves the cross-correlation between the recovered bone factor and the exposed bone measurement in a low signal-to-noise region of the bone spectra (p=0.0245). (C) 2008 Society of Photo-Optical Instrumentation Engineers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
