Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 13, Issue 2, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.2909671
Keywords
noninvasive monitoring; glucose; tissue; pressure; optical coherence tomography
Funding
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB001467] Funding Source: NIH RePORTER
- NIBIB NIH HHS [R01 EB001467] Funding Source: Medline
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We proposed to use optical coherence tomography (OCT) for continuous noninvasive blood glucose monitoring, and recently we significantly improved the sensitivity of this technique. The accuracy of OCT glucose monitoring is limited by several factors, including variation of tissue pressure exerted by the OCT probe. We studied the influence of high (> 10 kPa) and low (<1 kPa) pressure levels on OCT blood glucose monitoring. We showed that controlling external pressure to <1 kPa substantially improved the accuracy and reproducibility of OCT-based glucose monitoring. (C) 2008 Society of Photo-Optical Instrumentation Engineers.
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