Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 10, Issue 8, Pages 1501-1508Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2014.1954
Keywords
Copper-Cysteamine Complex; Nanoparticles; Photodynamic Therapy; Singlet Oxygen; Radiotherapy; Cancer; Penetration; X-Ray Activation
Funding
- U.S. Army Medical Research Acquisition Activity (USAMRAA) [W81XWH-10-1-0279, W81XWH-10-1-0234]
- DHS joint ARI program [2011-DN-077-ARI053-02, 2011-DN-077-ARI053-03, 2011-DN-077-ARI053-04]
- NSF
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Photodynamic therapy (PDT) has attracted ever-growing attention as a promising modality in the treatment of cancer. However, due to the poor tissue penetration by light, PDT has rarely been applied for treating deep- seated tumors. This problem can be solved if photosensitizers are activated by X-rays, which are able to penetrate deeply into tissues. Previous attempts using X-rays to activate photosensitizers were not very successful, since the traditional PDT photosensitizers could not efficiently be activated with X-rays. Here we exploit copper-cysteamine complex (Cu-Cy) nanoparticles as a new type of photosensitizer activated by X-ray for cancer treatment. The newly invented Cu-Cy nanoparticles can be activated directly by X-rays to produce singlet oxygen. In vitro and in vivo study on human breast cancer cells (MCF-7) have shown significant cell destruction using Cu-Cy nanoparticles under X-ray activation. The Cu-Cy nanoparticles are a novel and potent X-ray activated photosensitizer which can enable PDT for deep cancer treatment.
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