Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 10, Issue 7, Pages 1267-1276Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2014.1838
Keywords
Surface Plasmon; Gold Nanorod; PEGylation; Bioconjugation; Cancer Therapy
Funding
- National Cancer Institute [1R21CA152375-01]
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Nanomaterial-directed, photothermal ablation is a practical future approach for the treatment of early-stage bladder cancer. Using a new PEGylation technique with bi-functional nitrophenyl carbonate PEG (bi-NPC-PEG) that promotes uniform suspension of the nanomaterial in solution, we have shown that gold nanorods conjugated to an anti-EGFR antibody (nano-alpha EGFR) bind effectively to EGFR-expressing bladder cancer cells. The subsequent application of infrared light, specifically tuned to the plasmon resonance of the nanorods used in this work, allows for the specific heating of nano-alpha EGFR to the point of localized cellular death. Such an approach, administering nano-alpha EGFR intravesically via a urinary catheter and infrared light via a modified cystoscope, represents a novel, future clinical application of this technology, which avoids the problem of systemic exposure and clearance of nanoparticles from body.
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