Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 10, Issue 1, Pages 17-31Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2014.1761
Keywords
Hyaluronic Acid; Conjugate; Drug Delivery; Imaging Agent
Funding
- Basic Science Research Programs of MEST [20100027955, 2012012827]
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In recent years, hyaluronic acid ( HA) has attracted significant interest in development of drug delivery systems because of its intrinsic physicochemical and biological properties, including water solubility, viscoeleasticity, non-immunogenicity, biocompatibility, and biodegradability. In addition, HA has the ability to selectively bind specific receptors on the disease-related cells such as cancer cells and activated macrophages, followed by receptor-mediated endocytosis. Owing to these unique features, HA has been extensively used for development of the targetable carriers to deliver the therapeutic and imaging agents. In this review, we discuss the recent progress in various HA-based conjugates for cancer therapy and imaging, in which the active agents are covalently conjugated or physically encapsulated.
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