Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 9, Issue 3, Pages 403-408Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2013.1511
Keywords
Graphene; Neuron; Transparent Electrode; Biocompatibility
Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [20110022728, R31-2008-000-20012-0, R31-10026]
- Center for Advanced Soft Electronics under the Global Frontier Research Program of the Ministry of Education, Science and Technology [2011-0031628]
- GIST Specialized Research Program by GIST, Korea [GIST-K02360]
- WCU (World Class University) program through the Korea Science and Engineering Foundation
- Ministry of Health and Welfare, Republic of Korea [A091047]
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Among the most critical components in neuronal interfaces is the implanted electrode which requires the long-term stability of its electrical performance and biocompatibility of electrode material in contact with live neuronal cells. Reduced graphene oxide (rGO) renowned for its high electrical conductivity and optical transparency has shown great potential for a variety of applications such as transparent conducting electrodes and biosensors, and might be a potential candidate material for the next-generation neuronal interfaces. However, there have been only few systematic studies on graphene-based neuronal interfaces in terms of electrical conductivity and biocompatibility. In this report, we maintained rat hippocampal neurons on top of the rGO multilayers and observed that the viability of neurons is minimally affected and comparable to those grown on a glass substrate up to 30 days in vitro. These results implicate that rGO multilayer can be utilized for excellent neuronal interfaces with its high electrical conductivity and biocompatibility.
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