Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 8, Issue 5, Pages 730-741Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2012.1430
Keywords
Molecular Imaging; Lipid Nanoparticles; Fluorescence Imaging; IndoCyanine Green; EPR Effect; Tumor Detection; Lymph Node Detection
Funding
- Commissariat a l'Energie Atomique et aux Energies Alternatives
- French National Research Agency (ANR)
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Fluorescence imaging is opening a new era in image-guided surgery and other medical applications. The only FDA approved contrast agent in the near infrared is IndoCyanine Green (ICG), which despites its low toxicity, displays poor chemical and optical properties for long-term and sensitive imaging applications in human. Lipid nanoparticles are investigated for improving ICG optical properties and in vivo fluorescence imaging sensitivity. 30 nm diameter lipid nanoparticles (LNP) are loaded with ICG. Their characterization and use for tumor and lymph node imaging are described. Nano-formulation benefits dye optical properties (6 times improved brightness) and chemical stability (>6 months at 4 degrees C in aqueous buffer). More importantly, LNP vectorization allows never reported sensitive and prolonged (>1 day) labeling of tumors and lymph nodes. Composed of human-use approved ingredients, this novel ICG nanometric formulation is foreseen to expand rapidly the field of clinical fluorescence imaging applications.
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