Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 7, Issue 1, Pages 106-107Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2011.1224
Keywords
Graphene; Thermally Exfoliated Graphite Oxide; Human Lung Cells
Funding
- CSIR, New Delhi [NWP-35, OLP-09, OLP-06]
- Department of Science and Technology-UK India Education and Research Initiative (UKIERI) [DST/INT/UKIERI/SA/P-10/2008]
- DST-NSTI [SR/S5/NM-01/2007]
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Graphite nanomaterials such as thermally exfoliated graphite oxide (GO) are versatile in many applications. However, little is known about its effects on biological systems. In this study we characrerized the GO using dynamic light scattering (DLS) along with the toxicological aspects related to cytotoxicity and apoptosis in normal human lung cells (BEAS-2B). A significant concentration and time dependent decrease in cell viability was observed at different concentrations (10-100 mu g/ml) by the MTT assay after 24 and 48 h of exposure and significant increase of early and late apoptotic cells was observed as compared to control cells. Our study demonstrates that GO induces cytotoxicity and apoptosis in human lung cells.
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