Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 7, Issue 4, Pages 549-557Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2011.1316
Keywords
Poly(vinyl alcohol); Nano-Hydroxyapatite; Biological Evaluation; Guided Bone Regeneration Composite Membrane
Funding
- National High-Tech Project (863) [2007AA 021902]
- Specialized Research Fund for the Doctoral Program of Higher Education [SRFDP 200806100065]
- New Century Excellent Talents in University [NCET-08-0371]
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In this study, nano-hydroxyapatite/poly(vinyl alcohol) (n-HA/PVA) composite membranes were prepared by solvent casting and evaporation method. The morphology, mechanical properties, water absorption behavior, contact angle measurement and biocompatibility of these membranes were examined by SEM, FTIR, XRD, MU assay and etc. The results demonstrate that the surface of composite membranes is suitable for the adhesion and proliferation of osteogenic cells, and that n-HA and PVA are in uniform distribution when the content of n-HA is less than 20 wt%. Tests of swelling behavior and water contact angle show that the incorporation of n-HA into PVA matrix significantly reduces its hydrophilicity. Mechanical tests reveal that the addition of n-HA nanoparticles reduces tensile strength and elongation rate but increases Young's modulus of composite membranes. Cell attachment test and MU assay prove that n-HA/PVA composite membranes have good biocompatibility. Therefore, the n-HA/PVA composite membranes possess potential application for guided bone regeneration (GBR).
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