Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 6, Issue 4, Pages 312-317Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2010.1137
Keywords
Protein Polymers; Zein Nanoparticles; pH Nanoprecipitation; Biodegradation; Encapsulation Efficiency; Sustained Release
Funding
- South Dakota State Corn utilization Council
- Governor's 2010 competitive research seed grant
- Department of Pharmaceutical Sciences, South Dakota State University
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Zein is a hydrophobic water insoluble plant protein and the main goal of the present study was to prepare zein nanoparticles using pH controlled nanoprecipitation method. Nanoparticle characteristics such as size, polydispersity index (PI), zeta potential, and encapsulation efficiency were studied using 6, 7-dihydroxycoumarin, as a model hydrophobic compound. Lecithin and pluronic F68 were used as stabilizers. The blank zein nanoparticles had a mean particle size of 460 nm; while coumarin loaded zein nanoparticles had a mean particle size of 365 nm. The encapsulation efficiency of coumarin loaded zein nanoparticles was 62%. The release of coumarin from zein nanoparticles was sustained in phosphate buffer (pH 7.4) for upto 9 days. Overall the results from this study demonstrate a new method for preparing drug loaded zein nanoparticles.
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