Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 6, Issue 1, Pages 1-19Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2010.1098
Keywords
Nanoparticle; Nanomaterials; Toxicology; Air Pollution; Cellular Uptake; Reactive Oxygen; Cardiovascular; Pulmonary; Central Nervous System; Hepatic; Renal
Funding
- Medical Research Council [G19/34, G0800766] Funding Source: Medline
- Medical Research Council [G0800766, G19/34] Funding Source: researchfish
- MRC [G19/34, G0800766] Funding Source: UKRI
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The last decade has witnessed an unprecedented explosion in nanotechnology to take advantage of the unique physicochemical properties that emerge at the nanoscale including quantum effects. However, the excitement generated by new applications of nanotechnology in products has not been matched by a parallel appreciation or understanding of their potential toxic effects in humans and the wider ecology. This review draws some parallels to what we already know about the toxicity of particles in the workplace and in association with air pollution, and then discusses what is known about the toxicology of nanomaterials in mammals including humans. The review identifies substantial gaps in knowledge and makes some recommendations for future research.
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