4.5 Article

Antimicrobial and Anticancer Efficacy of Antineoplastic Agent Capped Gold Nanoparticles

Journal

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 6, Issue 2, Pages 129-137

Publisher

AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2010.1115

Keywords

Gold Nanoparticles; Thioguanine; Au@TG Complex; Antimicrobial and Anticancer Studies

Ask authors/readers for more resources

Synthesis of thioguanine (TG)-capped Au nanoparticles (Au@TG) and their enhanced in vitro antimicrobial and anticancer efficacy against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, E-Coli, Aspergillus fumigatus, Aspergillus niger and Hep2 cancer cell (Human epidermiod cell) have been reported. The nature of binding between 6-TG and the gold nanoparticles via complexation is investigated using ultraviolet visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The present experimental studies suggests that Au@TG are more potential than TG towards antimicrobial and anticancer activities. Hence, gold nanoparticles have the potential to be used as effective carriers for anticancer drug.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available