Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 4, Issue 3, Pages 349-358Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2008.321
Keywords
Poly(DL-lactide-co-glycolide); Folic Acid; Nanoparticles; IR; SEM; UV-Vis; Zeta Potential Measurements; Stereological Analysis; Drug Delivery
Funding
- The Ministry of Science and Environmental Protection of Republic of Serbia [142006]
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Biodegradable polymers have become the materials of choice for a variety of biomedical applications. In particular, poly(DL-lactide-co-glycolide) nanoparticles have been studied as a material for drug delivery with the controlled release. In this paper we are describing a simple method for obtaining the system for targeted and controlled delivery of folic acid in the body. Folic acid was encapsulated into the polymer matrix by means of homogenization of aqueous and organic phases. Concentration of folic acid in water was varied in order to obtain nanoparticles with different ratios of poly(DL-lactide-co-glycolide) and folic acid. The particles were obtained by physicochemical solvent/non-solvent method with polyvinyl pyrrolidone as a surfactant. The obtained particles are non-agglomerated, uniform and with particles size in the nanometer range. The samples were characterized using Infrared Spectroscopy (IR), Ultraviolet Spectroscopy (UV), Zeta potential measurements, Scanning Electron Microscopy (SEM) and Stereological analysis.
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