Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 103, Issue 6, Pages 1161-1167Publisher
WILEY
DOI: 10.1002/jbm.b.33294
Keywords
antibacterial implant coatings; hydroxyapatite; calcium hydroxide; isothermal microcalorimetry; Staphylococcus
Funding
- Swiss Nanoscience Institute
- Swiss National Science Foundation [51NF40-144618]
- Forschungsfonds Kanton Aargau [120331_6_ELBACOSS]
- Swiss Commission for Innovation [15119.1 INNO12-LS]
- Swiss National Science Foundation (SNF) [51NF40-144618] Funding Source: Swiss National Science Foundation (SNF)
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Biomaterials with antimicrobial properties are now commonly used in different clinical specialties including orthopedics, endodontic, and traumatology. As a result, assessing the antimicrobial effect of coatings applied on implants is of critical importance. In this study, we demonstrate that isothermal microcalorimetry (IMC) can be used for monitoring bacterial growth and biofilm formation at the surface of such coatings and for determining their antimicrobial effects. The antibacterial effects of silver doped hydroxyapatite (HA) and calcium hydroxide coatings on Staphylococcus epidermidis were determined with a minimal workload. Using the Gompertz growth model we determined biofilm growth rates close to those values reported in the literature. Furthermore, we were able to estimate the reduction in the bacterial inocula originally applied at the surface of the coatings. Therefore, in addition to monitoring the antimicrobial effect of silver doped HA and calcium hydroxide coatings, we also demonstrate that IMC might be a valuable tool for assessing such antimicrobial properties of implant coatings at a minimal workload. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1161-1167, 2015.
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