Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 102, Issue 8, Pages 1689-1699Publisher
WILEY-BLACKWELL
DOI: 10.1002/jbm.b.33146
Keywords
fluid shear stress; cellular growth; numerical modeling; titanium porous structures; additive manufacturing
Funding
- Research Complex at Harwell
- EPSRC [EP/IO2249X/1]
- EPSRC [EP/I02249X/1, EP/I020861/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I02249X/1, EP/I020861/1] Funding Source: researchfish
Ask authors/readers for more resources
Bone augmentation implants are porous to allow cellular growth, bone formation and fixation. However, the design of the pores is currently based on simple empirical rules, such as minimum pore and interconnects sizes. We present a three-dimensional (3D) transient model of cellular growth based on the Navier-Stokes equations that simulates the body fluid flow and stimulation of bone precursor cellular growth, attachment, and proliferation as a function of local flow shear stress. The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures. The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomized structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates. This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what-if simulations to design AM structures to specific functional requirements. (C) 2014 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available