Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 96B, Issue 2, Pages 342-350Publisher
WILEY
DOI: 10.1002/jbm.b.31775
Keywords
allograft; absorbable; hydroxyapatite; nanomaterials; histomorphometry
Ask authors/readers for more resources
The purpose of this study was to evaluate biomaterial degradation and new bone formation after implantation of a nanostructured hydroxyapatite (HA) grafting block. Furthermore, physical characteristics of the biomaterial were measured. The biomaterial consists of nanostructured HA embedded in a porous matrix of silica (SiO2) gel. The blocks with two different contents of silica (group A: 24 wt % and group B: 39 wt %) were fixed with titanium screws at the lateral aspect of the mandible of minipigs (n = 5). The specific surface areas of both blocks were measured using Brunauer-Emmett-Teller (BET) equation and mercury intrusion. In all animals, the wound healing was uneventful. After 5 weeks, the biomaterial percentage was 51.5% +/- 12.1% for group A and 33.2% +/- 5.9% for group B (p = 0.017). New bone formation accounted to 7.6% +/- 6.0% for group A and 15.3% +/- 8.3% for group B (p = 0.126) after 5 weeks. After 10 weeks, further resorption of the biomaterial led to percentages of 30.6% +/- 10.0% for group A and 12.1% +/- 6.7% for group B (p = 0.000). After 10 weeks, new bone formations were measured to be 34.1% +/- 10.8% in group A and 39.9% +/- 13.5% in group B (p = 0.383). The rate of degradation of the biomaterial is controlled by the composition of the material. A higher content of silica gel matrix leads to faster degradation of the biomaterial. The formation of new bone failed to show a significant difference between both groups. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 96B: 342-350, 2011.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available