Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 93B, Issue 2, Pages 562-572Publisher
WILEY
DOI: 10.1002/jbm.b.31617
Keywords
controlled drug release; extrusion; implant; poly-lactic-co-glycolic acid (PLGA); scanning electron microscopy (SEM); formulation
Funding
- Stanley Medical Research Institute [RCG 01-314]
- National Institute of Mental Health [R01MH074672-01]
Ask authors/readers for more resources
Low compliance with medication is the major cause of poor outcome in schizophrenia treatment While surgically implantable solvent-cast pellets were produced to improve outcome by increased compliance with medication, this process is laborious and time-consuming, inhibiting its broader application (Siegel et al, Eur J Pharm Biopharm 2006,64 287-293) In this study, the previous fabrication process was translated to a continuous and scalable extrusion method Extrusion processes were modified based on in vitro release studies, drug load consistency examination, and surface morphology analysis using scanning electron microscopy Afterward, optimized haloperidol implants were implanted into rats for preliminary analysis of biocompatibility Barrel temperature, screw speed and resulting processing pressure influenced surface morphology and drug release Data suggest that fewer surface pores shift the mechanism from bulk to surface PLGA degradation and longer lag period Results demonstrate that extrusion is a viable process for manufacturing antipsychotic implants (C) 2010 Wiley Periodicals, Inc J Biomed Mater Res Part B Appl Biomater 93B 562-572, 2010
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available