Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 93B, Issue 2, Pages 324-332Publisher
WILEY
DOI: 10.1002/jbm.b.31562
Keywords
peptide; self-assembly; hydrogel; biocompatibility
Funding
- National Natural Science Foundation of China [30772382, 20774069, 50633020]
- National Key Basic Research Program of China [2005CB623903]
Ask authors/readers for more resources
A peptide containing a RGD (arginine-glycine-aspartic acid) sequence as well as a hydrophobic N-fluorenyl-9-methoxycarbonyl (FMOC) tail was prepared via a standard FMOC solid-phase peptide synthesis technique. The supramolecular self-assembly of such peptide through pi-pi stacking from FMOC tail can transfer the peptide aqueous solution into a three-dimensional hydrogel. The biocompatibility of the peptide hydrogel was evaluated via clinical follow-up and histological analysis. The data obtained demonstrated that the peptide hydrogel exhibited good biocompatibility when injected to the subconjunctival space and anterior chamber of rabbit, indicating a potential application in ophthalmology as an implantable drug delivery system for the treatment to ocular anterior segment diseases such as glaucoma, iridocyclitis, and keratopathy. (C) 2010 Wiley Periodicals. Inc J Filmed Mater Res Part B Appl Biomater 93B 324-332, 2010
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available