Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 88B, Issue 1, Pages 290-303Publisher
WILEY
DOI: 10.1002/jbm.b.31151
Keywords
heart valve replacement; polymers; tissue engineering; percutaneous heart valves
Funding
- Engineering and Physical Sciences Research Council [EPSRC EP/D061555]
- British Heart Foundation
- EPSRC [EP/D061555/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D061555/1] Funding Source: researchfish
- National Institute for Health Research [J003] Funding Source: researchfish
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Valve replacement is the most common surgical treatment in patients with advanced valvular heart disease. Mechanical and bio-prostheses have been the traditional heart valve replacements in these patients. However, currently the heart valves for replacement therapy are imperfect and subject patients to one or more ongoing risks, including thrombosis, limited durability. and need for re-operations due to the lack of growth in pediatric populations. Furthermore, they require an open heart surgery, which is risky for elderly and young children Who are too weak or ill to undergo major surgery. This article reviews the current state of the art of heart valve replacements in light of their potential clinical applications. In recent years polymeric materials have been widely studied as potential prosthetic heart valve material being designed to overcome the clinical problems associated with both mechanical and bio-prosthetic valves. The review also addresses the advances in polymer materials, tissue engineering approaches, and the development of percutaneous valve replacement technology and discusses the future prospects in these fields. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 88B: 290-303, 2009
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