Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 90B, Issue 1, Pages 467-475Publisher
WILEY
DOI: 10.1002/jbm.b.31281
Keywords
antimicrobial; bone cement; PMMA; acrylic; infection
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Antibiotic-loaded acrylic bone cement is a well-established tool in the prophylaxis and treatment of orthopedic infections. Numerous studies about its pharmacokinetic properties have demonstrated that only a small part of the incorporated antibiotic amounts can be released, mostly over the first 8-10 weeks. Therefore, in the past 10 years, several attempts have been made for enhancement of the drug elution from bone cement. This article reviews this experience and pays special attention on biantibiotic combinations, additives other than antimicrobial agents, as well as the effect of ultrasound on the antibiotic elution characteristics. (c) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part 13: Appl Biomater 90B: 467-475. 2009
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